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Papers of the Week

2022 Jan 12

Reg Anesth Pain Med

Association of perioperative midazolam use and complications: a population-based analysis.


Athanassoglou V, Cozowicz C, Zhong H, Illescas A, Poeran J, Liu J, Poultsides L, Memtsoudis SG
Reg Anesth Pain Med. 2022 Jan 12.
PMID: 35022262.


The benzodiazepine midazolam is the main sedative used in the perioperative setting, resulting in anxiolysis and a reduction in anesthetic dose requirements. However, benzodiazepine use is also associated with potentially serious side effects including respiratory complications, and postoperative delirium (POD). A paucity of population level data exists on current perioperative midazolam use in adult orthopedic surgery and its effects on complications. Using a large national dataset, we aimed to determine perioperative midazolam utilization patterns and to analyze its effect on postoperative outcomes.