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Papers: 15 Jan 2022 - 21 Jan 2022

2022 Jan 13

BMJ Open



Human assumed central sensitisation (HACS) in patients with chronic low back pain radiating to the leg (CLaSSICO study).


Schuttert I, Timmerman H, Groen GJ, Petersen K K, Arendt-Nielsen L, Wolff AP
BMJ Open. 2022 Jan 13; 12(1):e052703.
PMID: 35027419.


Patients with chronic low back pain radiating to the leg (CLBPr) are sometimes referred to a specialised pain clinic for a precise diagnosis based, for example, on a diagnostic selective nerve root block. Possible interventions are therapeutic selective nerve root block or pulsed radiofrequency. Central pain sensitisation is not directly assessable in humans and therefore the term 'human assumed central sensitisation' (HACS) is proposed. The possible existence and degree of sensitisation associated with pain mechanisms assumed present in the human central nervous system, its role in the chronification of pain and its interaction with diagnostic and therapeutic interventions are largely unknown in patients with CLBPr. The aim of quantitative sensory testing (QST) is to estimate quantitatively the presence of HACS and accumulating evidence suggest that a subset of patients with CLBPr have facilitated responses to a range of QST tests.The aims of this study are to identify HACS in patients with CLBPr, to determine associations with the effect of selective nerve root blocks and compare outcomes of HACS in patients to healthy volunteers.