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Papers of the Week

2022 Jan 14

Medicine (Baltimore)



Gastric neuroendocrine neoplasms and precursor lesions: Case reports and literature review.


Boeriu A, Dobru D, Fofiu C, Brusnic O, Onişor D, Mocan S
Medicine (Baltimore). 2022 Jan 14; 101(2):e28550.
PMID: 35029217.


Gastric neuroendocrine neoplasms (g-NENs) represent a distinctive group of gastric tumors, stratified into different prognostic categories according to different histological characteristics, put forth in the 2018 World Health Organization classification system. The clinical presentations, as well as pathological features, represent important data in establishing the type of the tumor, in estimating the tumor behavior, and in selecting the best therapeutic strategy. In our case series we presented different clinical scenarios that may be encountered in practice regarding gastric NENs. We performed a literature review and discussed diagnostic strategy, current classification system, precursor lesions, and therapeutic options in g-NENs.