() commonly known as 'Kiswara' is used as infusions for stomach and joint pain. This study aims to evaluate the and anti-inflammatory and anti-arthritic activity was evaluated by measuring inflammatory parameters (TNF-, C-reactive protein and Fibrinogen) in murine models of the aqueous extract and isolated compounds of . A bio-guided phytochemical analysis based on NMR/MS was performed identifying three (-) compounds of the aqueous extract. All compounds inhibited the production of TNF- in RAW 264.7 cell line, with IC of 13.44 (), 1.13 () and 0.57 μM (), respectively. In addition, compounds and decreased the levels of TNF-, C-reactive protein and fibrinogen at a concentration of 5 mg/kg in murine models. Our research shows that the compounds isolated from have anti-inflammatory and anti-arthritic properties, providing scientific evidence for the traditional use of this plant species.