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Papers of the Week

2022 Jan 10

Nat Prod Res

Anti-inflammatory and anti-arthritic effects of compounds from .


Apaza Ticona L, Siñani Callisaya GB, Aguilar Rico F, Sánchez Sánchez-Corral J, Slowing K
Nat Prod Res. 2022 Jan 10:1-5.
PMID: 35007169.


() commonly known as 'Kiswara' is used as infusions for stomach and joint pain. This study aims to evaluate the and anti-inflammatory and anti-arthritic activity was evaluated by measuring inflammatory parameters (TNF-, C-reactive protein and Fibrinogen) in murine models of the aqueous extract and isolated compounds of . A bio-guided phytochemical analysis based on NMR/MS was performed identifying three (-) compounds of the aqueous extract. All compounds inhibited the production of TNF- in RAW 264.7 cell line, with IC of 13.44 (), 1.13 () and 0.57 μM (), respectively. In addition, compounds and decreased the levels of TNF-, C-reactive protein and fibrinogen at a concentration of 5 mg/kg in murine models. Our research shows that the compounds isolated from have anti-inflammatory and anti-arthritic properties, providing scientific evidence for the traditional use of this plant species.