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Papers of the Week
The industrial solvent 1,4-dioxane causes hyperalgesia by targeting capsaicin receptor TRPV1.
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Abstract
The synthetic chemical 1,4-dioxane is used as industrial solvent, food, and care product additive. 1,4-Dioxane has been noted to influence the nervous system in long-term animal experiments and in humans, but the molecular mechanisms underlying its effects on animals were not previously known.