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Papers of the Week

Papers: 8 Jan 2022 - 14 Jan 2022

Pharmacology/Drug Development

2022 Jan 07

BMC Biol



The industrial solvent 1,4-dioxane causes hyperalgesia by targeting capsaicin receptor TRPV1.


Mo X, Liu Q, Gao L, Xie C, Wei X, Pang P, Tian Q, Gao Y, Zhang Y, Wang Y, Xiong T, Zhong B, Li D, Yao J
BMC Biol. 2022 Jan 07; 20(1):10.
PMID: 34996439.


The synthetic chemical 1,4-dioxane is used as industrial solvent, food, and care product additive. 1,4-Dioxane has been noted to influence the nervous system in long-term animal experiments and in humans, but the molecular mechanisms underlying its effects on animals were not previously known.