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Papers of the Week

Papers: 1 Jan 2022 - 7 Jan 2022

Pharmacology/Drug Development

2022 Jan 03

J Headache Pain



IL-17 crosses the blood-brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine.


Chen H, Tang X, Li J, Hu B, Yang W, Zhan M, Ma T, Xu S
J Headache Pain. 2022 Jan 03; 23(1):1.
PMID: 34979902.


Chronic migraine places a disabling burden on patients, which is extensively modeled by the nitroglycerin (NTG)-treated animal model. Although the NF-κB pathway is involved in an increase in CGRP levels and activation of the trigeminal system in the NTG model, the relationship between NTG and neuroinflammation remains unclear. This study aimed to optimize a chronic NTG rat model with hyperalgesia and the ethological capacity for estimating migraine therapies and to further explore the underlying mechanism of NTG-induced migraine.