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Papers of the Week

Papers: 25 Dec 2021 - 31 Dec 2021

2021 Dec 29

Brain Behav

Altered brain activity in end-stage knee osteoarthritis revealed by resting-state functional magnetic resonance imaging.


Kang B-X, Ma J, Shen J, Xu H, Wang H-Q, Zhao C, Xie J, Zhong S, Gao C-X, Xu X-R, A X-Y, Gu X-L, Xiao L, Xu J
Brain Behav. 2021 Dec 29:e2479.
PMID: 34967156.


Knee osteoarthritis (KOA) is characterized by a degenerative change of knee cartilage and secondary bone hyperplasia, resulting in pain, stiffness, and abnormal walking gait. Long-term chronic pain causes considerable cortical plasticity alternations in patients. However, the brain structural and functional alterations associated with the pathological changes in knee joints of end-stage KOA patients remain unclear. This study aimed to analyze the structural and functional connectivity alterations in end-stage KOA to comprehensively understand the main brain-associated mechanisms underlying its development and progression.