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Papers of the Week

Papers: 25 Dec 2021 - 31 Dec 2021

Animal Studies, Pharmacology/Drug Development

2021 Dec 23

Cell Mol Gastroenterol Hepatol

Gut-innervating TRPV1+ neurons drive chronic visceral pain via microglial P2Y12 receptor.


Defaye M, Abdullah NS, Iftinca M, Hassan A, Agosti F, Zhang Z, Cumenal M, Zamponi GW, Altier C
Cell Mol Gastroenterol Hepatol. 2021 Dec 23.
PMID: 34954381.


Chronic abdominal pain is a common symptom of inflammatory bowel diseases (IBD). Peripheral and central mechanisms contribute to the transition from acute to chronic pain during active disease and clinical remission. Lower mechanical threshold and hyperexcitability of visceral afferents induce gliosis in central pain circuits, leading to persistent visceral hypersensitivity (VHS). In the spinal cord, microglia, the immune sentinels of the central nervous system, undergo activation in multiple models of VHS. Here we investigated the mechanisms of microglia activation to identify centrally acting analgesics for chronic IBD pain.