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Front Pharmacol


Lyophilized Symbiotic Mitigates Mucositis Induced by 5-Fluorouracil.


Savassi B, Cordeiro BF, Silva SH, Oliveira ER, Belo G, Figueiroa A G, Alves Queiroz M I, Faria A M C, Alves J, da Silva T F, Campos G M, Esmerino EA, Rocha RS, Freitas MQ, Silva MC, Cruz AG, Vital K D, Fernandes SOA, Cardoso VN, Acurcio L B, et al.
Front Pharmacol. 2021; 12:755871.
PMID: 34955828.


Mucositis is an adverse effect of cancer chemotherapies using 5-Fluorouracil (5-FU). It is characterized by mucosal inflammation, pain, diarrhea, and weight loss. Some studies reported promising healing effects of probiotic strains, when associated with prebiotics, as adjuvant treatment of mucositis. We developed a lyophilized symbiotic product, containing skimmed milk, supplemented with whey protein isolate (WPI) and with fructooligosaccharides (FOS), and fermented by BL23, B7, and B1. In a mice 5-FU mucositis model, this symbiotic lyophilized formulation was able to reduce weight loss and intestinal permeability. This last was determined by quantifying blood radioactivity after oral administration of 99mTc-DTPA. Finally, histological damages caused by 5-FU-induced mucositis were monitored. Consumption of the symbiotic formulation caused a reduced score of inflammation in the duodenum, ileum, and colon. In addition, it decreased levels of pro-inflammatory cytokines IL-1β, IL-6, IL-17, and TNF-α in the mice ileum. The symbiotic product developed in this work thus represents a promising adjuvant treatment of mucositis.