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Papers of the Week

Papers: 18 Dec 2021 - 24 Dec 2021

Pharmacology/Drug Development

2021 Nov-Dec

Pain Rep



Use of methadone as an alternative to morphine for chronic pain management: a noninferiority retrospective observational study.


de Barros G A M, Baradelli R, Rodrigues D G, Toffoletto O, Domingues F S, Gayoso M V, Lopes A, Barros Afiune J, Nunes Guimarães G M
Pain Rep. 2021 Nov-Dec; 6(4):e979.
PMID: 34938934.


Chronic pain causes disability and is prevalent in the general population. Opioids are a part of a multimodal strategy for pain management. Methadone, a cheap and long-acting synthetic opioid, may represent an option for those who have limited access to the aforementioned class of analgesics. We aimed to provide a real-world evidence for the analgesic use of methadone, compared with morphine.