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Papers of the Week

Papers: 11 Dec 2021 - 17 Dec 2021

Human Studies

2021 Dec 13

J Headache Pain



Increase in ACC GABA+ levels correlate with decrease in migraine frequency, intensity and disability over time.


Peek AL, Leaver AM, Foster S, Puts NA, Oeltzschner G, Henderson L, Galloway G, Ng K, Refshauge K, Rebbeck T
J Headache Pain. 2021 Dec 13; 22(1):150.
PMID: 34903165.


An imbalance between inhibitory and excitatory neurometabolites has been implicated in chronic pain. Prior work identified elevated levels of Gamma-aminobutyric acid + macromolecules ("GABA+") using magnetic resonance spectroscopy (MRS) in people with migraine. What is not understood is whether this increase in GABA+ is a cause, or consequence of living with, chronic migraine. Therefore, to further elucidate the nature of the elevated GABA+ levels reported in migraine, this study aimed to observe how GABA+ levels change in response to changes in the clinical characteristics of migraine over time.