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Papers of the Week

Papers: 11 Dec 2021 - 17 Dec 2021

Pharmacology/Drug Development

2022 Jan 01

Anesth Analg



Inflammatory Biomarker Levels After Propofol or Sevoflurane Anesthesia: A Meta-analysis.


O'Bryan LJ, Atkins KJ, Lipszyc A, Scott DA, Silbert BS, Evered LA
Anesth Analg. 2022 Jan 01; 134(1):69-81.
PMID: 34908547.


The perioperative inflammatory response may be implicated in adverse outcomes including neurocognitive dysfunction and cancer recurrence after oncological surgery. The immunomodulatory role of anesthetic agents has been demonstrated in vitro; however, its clinical relevance is unclear. The purpose of this meta-analysis was to compare propofol and sevoflurane with respect to biomarkers of perioperative inflammation. The secondary aim was to correlate markers of inflammation with clinical measures of perioperative cognition.