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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation.

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Papers: 4 Dec 2021 - 10 Dec 2021


Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2021 Dec 04


J Headache Pain


http://www.ncbi.nlm.nih.gov/pubmed/34863113?dopt=Abstract


22


1

Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation.

Authors

Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation.
Nie L, Ma D, Quinn JP, Wang M
J Headache Pain. 2021 Dec 04; 22(1):146.
PMID: 34863113.

Abstract

Purinergic P2X7 receptor plays an important role in migraine pathophysiology. Yet precise molecular mechanism underlying P2X7R signaling in migraine remains unclear. This study explores the hypothesis that P2X7 receptor transmits signaling to Src family kinases (SFKs) during cortical spreading depression (CSD) and neuroinflammation after CSD.
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