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Papers of the Week

Papers: 4 Dec 2021 - 10 Dec 2021

Animal Studies

2021 Dec 02

J Neuroinflammation



Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn.


Heles M, Mrozkova P, Sulcova D, Adamek P, Spicarova D, Palecek J
J Neuroinflammation. 2021 Dec 02; 18(1):279.
PMID: 34857006.


Opioid analgesics remain widely used for pain treatment despite the related serious side effects. Some of those, such as opioid tolerance and opioid-induced hyperalgesia may be at least partially due to modulation of opioid receptors (OR) function at nociceptive synapses in the spinal cord dorsal horn. It was suggested that increased release of different chemokines under pathological conditions may play a role in this process. The goal of this study was to investigate the crosstalk between the µOR, transient receptor potential vanilloid 1 (TRPV1) receptor and C-C motif ligand 2 (CCL2) chemokine and the involvement of spinal microglia in the modulation of opioid analgesia.