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Papers of the Week

Papers: 27 Nov 2021 - 3 Dec 2021

Pharmacology/Drug Development


J Pain Res


Dose-Related Inhibition of Capsaicin Responses by Cannabinoids CBG, CBD, THC and their Combination in Cultured Sensory Neurons.


Anand U, Oldfield C, Pacchetti B, Anand P, Sodergren MH
J Pain Res. 2021; 14:3603-3614.
PMID: 34853533.


The analgesic effects of are mediated by ∆ tetrahydrocannabinol (THC), but the contributions of other bioactive complex components, including cannabigerol (CBG) and cannabidiol (CBD), are unclear. We describe the individual and combined effects of CBG, CBD and THC, on blocking capsaicin responses in dorsal root ganglion (DRG) neurons, in an in vitro model of nociceptor hypersensitivity.