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Papers of the Week

2021 Aug

Transl Androl Urol



Neuroinflammatory gene expression in chronic prostatitis/chronic pelvic pain syndrome patients: insights into etiology and phenotype biology.


Shoskes DA, Keslar KS, Gotwald P, Berglund R, Vij S
Transl Androl Urol. 2021 Aug; 10(8):3340-3347.
PMID: 34532258.


Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has diverse clinical phenotypes and its etiology is multifactorial. Studies to date of gene expression in humans have been limited to small numbers of target genes. NanoString can simultaneously measure hundreds of genes. We wished to study gene expression in blood and urine of CP/CPPS patients compared to controls for neuroinflammatory genes and characterize the results by patient phenotype.