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Papers of the Week


J Alzheimers Dis



Mild Cognitive Impairment and Decline in Resting State Functional Connectivity after Total Knee Arthroplasty with General Anesthesia.


Hardcastle C, Huang H, Crowley S, Tanner J, Hernaiz C, Rice M, Parvataneni H, Ding M, Price CC
J Alzheimers Dis. 2019; 69(4):1003-1018.
PMID: 31104019.


Research shows that older adults can have a decline in three key resting state networks (default mode network, central executive network, and salience network) after total knee arthroplasty and that patients' pre-surgery brain and cognitive integrity predicts decline.