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Papers of the Week

Papers: 31 Jul 2021 - 6 Aug 2021

Pharmacology/Drug Development

2021 Aug

Pain Physician



Epidural Injections for Lumbar Radiculopathy or Sciatica: A Comparative Systematic Review and Meta-Analysis of Cochrane Review.


Manchikanti L, Knezevic E, Knezevic N N, Sanapati MR, Thota S, Abd-Elsayed A, Hirsch JA
Pain Physician. 2021 Aug; 24(5):E539-E554.
PMID: 34323441.


Epidural injections are one of the commonly performed procedures in managing low back and lower extremity pain. In the past, Pinto et al and Chou et al performed systematic reviews and meta-analyses with a recent update from Oliveira et al showing lack of effectiveness of epidural steroid injections in managing lumbar radiculopathy. In contrast, multiple other systematic reviews and meta-analyses have supported the efficacy and use of epidural injections utilizing fluoroscopic guidance.