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Papers of the Week

2021 Jul 26

Ann Anat

Intraneural fibrosis and loss of microvascular architecture – Key findings investigating failed human nerve allografts.


Zucal I, Mihic-Probst D, Pignet A-L, Calcagni M, Giovanoli P, Frueh FS
Ann Anat. 2021 Jul 26:151810.
PMID: 34324996.


Processed nerve allografts are increasingly used in clinical nerve reconstruction with promising results. However, allograft failure has been reported, leading to chronic pain and persistent loss of function. In the present work, we performed a histological and immunohistochemical analysis of two failed allograft reconstructions of a sensory human nerve one year after primary surgery.