I am a
Home I AM A Search Login

Papers of the Week

2021 Jun 29



Koumine modulates spinal microglial M1 polarization and the inflammatory response through the Notch-RBP-Jκ signaling pathway, ameliorating diabetic neuropathic pain in rats.


Jin G-L, Hong L-M, Liu H-P, Yue R-C, Shen Z-C, Yang J, Xu Y, Huang H-H, Li Y, Xiong B-J, Su Y-P, Yu C-X
Phytomedicine. 2021 Jun 29; 90:153640.
PMID: 34330066.


Diabetic neuropathic pain (DNP), a complication of diabetes, has serious impacts on human health. As the pathogenesis of DNP is very complex, clinical treatments for DNP is limited. Koumine (KM) is an active ingredient extracted from Gelsemium elegans Benth. that exerts an inhibitory effect on neuropathic pain (NP) in several animal models.