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Papers of the Week

Papers: 17 Jul 2021 - 23 Jul 2021


Animal Studies, Pharmacology/Drug Development

2021 Jul 21

Neuropsychopharmacol Rep

Resolvin D2 attenuates chronic pain-induced depression-like behavior in mice.


Suzuki H, Hitora-Imamura N, Deyama S, Minami M
Neuropsychopharmacol Rep. 2021 Jul 21.
PMID: 34291613.


We previously demonstrated that intracerebroventricular injection of resolvin D2 (RvD2), a bioactive lipid mediator derived from docosahexaenoic acid, ameliorated depression-like behavior in lipopolysaccharide-induced and chronic mild stress-induced mouse models of depression. In the present study, we examined the antidepressant effect of RvD2 on chronic pain-induced depression-like behavior.