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Papers of the Week

Papers: 17 Jul 2021 - 23 Jul 2021

Animal Studies, Pharmacology/Drug Development

2021 Jul 21

Br J Pharmacol

Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared to human receptors.


Garelja ML, Bower RL, Brimble MA, Chand S, Harris PWR, Jamaluddin M A, Petersen J, Siow A, Walker CS, Hay DL
Br J Pharmacol. 2021 Jul 21.
PMID: 34289083.


The calcitonin (CT) receptor family is complex, comprising two receptors (the CT receptor [CTR], and the CTR-like receptor [CLR]), three accessory proteins (RAMPs), and multiple endogenous peptides. This family contains several important drug targets, including CGRP which is targeted by migraine therapeutics. The pharmacology of this receptor family is poorly characterised in species other than rats and humans. To facilitate understanding of translational and pre-clinical data we need to know the receptor pharmacology of this family in mice.