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Papers of the Week

Papers: 17 Jul 2021 - 23 Jul 2021

Animal Studies

2021 Jul-Aug

Pain Rep



The methyl donor S-adenosyl methionine reverses the DNA methylation signature of chronic neuropathic pain in mouse frontal cortex.


Topham L, Gregoire S, Kang HM, Salmon-Divon M, Lax E, Millecamps M, Szyf M, Stone L
Pain Rep. 2021 Jul-Aug; 6(2):e944.
PMID: 34278163.


Chronic pain is associated with persistent but reversible structural and functional changes in the prefrontal cortex (PFC). This stable yet malleable plasticity implicates epigenetic mechanisms, including DNA methylation, as a potential mediator of chronic pain-induced cortical pathology. We previously demonstrated that chronic oral administration of the methyl donor S-adenosyl methionine (SAM) attenuates long-term peripheral neuropathic pain and alters global frontal cortical DNA methylation. However, the specific genes and pathways associated with the resolution of chronic pain by SAM remain unexplored.