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Papers of the Week

Papers: 17 Jul 2021 - 23 Jul 2021

Pharmacology/Drug Development

2021 Jul 16

Curr Pain Headache Rep



Ketamine in the Past, Present, and Future: Mechanisms, Metabolites, and Toxicity.


Schwenk ES, Pradhan B, Nalamasu R, Stolle L, Wainer IW, Cirullo M, Olsen A, Pergolizzi JV, Torjman MC, Viscusi ER
Curr Pain Headache Rep. 2021 Jul 16; 25(9):57.
PMID: 34269883.


While ketamine's analgesia has mostly been attributed to antagonism of N-methyl-D-aspartate receptors, evidence suggests multiple other pathways are involved in its antidepressant and possibly analgesic activity. These mechanisms and ketamine's role in the nociplastic pain paradigm are discussed. Animal studies demonstrating ketamine's neurotoxicity have unclear human translatability and findings from key rodent and human studies are presented.