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Papers: 17 Jul 2021 - 23 Jul 2021
Pharmacology/Drug Development
2021 Jul 16
Curr Pain Headache Rep
25
9
While ketamine's analgesia has mostly been attributed to antagonism of N-methyl-D-aspartate receptors, evidence suggests multiple other pathways are involved in its antidepressant and possibly analgesic activity. These mechanisms and ketamine's role in the nociplastic pain paradigm are discussed. Animal studies demonstrating ketamine's neurotoxicity have unclear human translatability and findings from key rodent and human studies are presented.