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Papers of the Week

Papers: 10 Jul 2021 - 16 Jul 2021

Human Studies


2021 Jul 13


The molecular clock gene cryptochrome 1 (CRY1) and its role in cluster headache.


Fourier C, Ran C, Sjöstrand C, Waldenlind E, Steinberg A, Belin A C
Cephalalgia. 2021 Jul 13:3331024211024165.
PMID: 34256648.


Cluster headache is a severe primary headache disorder commonly featuring a strikingly distinct circadian attack pattern. Therefore, the circadian system has been suggested to play a crucial role in the pathophysiology of cluster headache. Cryptochromes are key components of the molecular clock generating circadian rhythms and have previously been shown to be associated with several psychiatric disorders, including seasonal affective disorder, bipolar disorder, and depression.