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Papers of the Week

Papers: 10 Jul 2021 - 16 Jul 2021

Animal Studies, Pharmacology/Drug Development

2021 Jul 13


Targeting reactive nitroxidative species in preclinical models of migraine.


Akerman S, Salvemini D, Romero-Reyes M
Cephalalgia. 2021 Jul 13:3331024211017884.
PMID: 34256650.


Reactive nitroxidative species, such as nitric oxide but particularly peroxynitrite, have been strongly implicated in pain mechanisms. Targeting peroxynitrite is anti-nociceptive in pain models, but little is known about its role in migraine mechanisms. Given the need to validate novel targets for migraine headache, our objective was to study the potential of reactive nitroxidative species, particularly peroxynitrite, as novel targets for drug discovery and their role in migraine mechanisms.