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Papers of the Week

Papers: 10 Jul 2021 - 16 Jul 2021

Human Studies

2021 Jul 02

JMIR Res Protoc



Investigating the Mechanisms of Graded Sensorimotor Precision Training in Adults With Chronic Nonspecific Low Back Pain: Protocol for a Causal Mediation Analysis of the RESOLVE Trial.


Cashin AG, Lee H, Bagg MK, Wand BM, O'Hagan E, Rizzo RRN, Stanton TR, Moseley LG, McAuley JH
JMIR Res Protoc. 2021 Jul 02; 10(7):e26053.
PMID: 34255720.


Chronic low back pain (CLBP) is a global health problem associated with an increasing burden on individuals, health care systems, and society. Common treatments for people with CLBP produce, on average, small short-term improvements in pain and function compared with minimal care. The RESOLVE trial randomly allocated 276 people with CLBP to a new complex treatment strategy, pain education integrated with graded sensorimotor precision training (RESOLVE), or a sham control. The RESOLVE treatment was developed within a theoretical framework to target possible treatment mechanisms associated with CLBP development and persistence.