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Papers of the Week

2021 Jul

Brain Nerve



[Pain Signal Processing in the Spinal Dorsal Horn and Glial Cells].


Tsuda M
Brain Nerve. 2021 Jul; 73(7):803-810.
PMID: 34234038.


Pain signals from the skin are transmitted to the spinal dorsal horn via primary afferent sensory neurons, appropriately processed, and transmitted to the brain. Neuropathic pain is a pathological condition that results from structural and functional changes that occur after nerve damage. Glial cells are crucial to these changes and play important roles in developing and maintaining neuropathic pain. This review article will outline glial cells' mechanism of action in neuropathic pain and discuss the development of potential analgesics.