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Papers of the Week

2021 Jul 08

Int J Clin Pharmacol Ther

Microdialysis as a potential tool for comparative assessment of tissue pharmacokinetics of two different patches containing lidocaine: A crossover pilot study.


Matzneller P, Oesterreicher Z, Wulkersdorfer B, Al Jalali V, Mascher D, Mascher H, Zeitlinger M
Int J Clin Pharmacol Ther. 2021 Jul 08.
PMID: 34236302.


Lidocaine 5% patches are approved for the treatment of post-herpetic neuralgia in adults. Little information is available on the penetration of lidocaine into skin and skin-related soft tissue, which are thought to be closer to the site where lidocaine exerts its pharmacological action on neuronal structures. This pilot study investigated subcutaneous and systemic pharmacokinetics of lidocaine during topical application of two different lidocaine 5% patches.