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Papers of the Week

2021 Jul 06

Transplant Proc

The Role of Dexmedetomidine in Hepatic Ischemia-Reperfusion Injury Via a Nitric Oxide-Dependent Mechanism in Rats.


Lee J E, Jung H, Cho J D, Choi E K, Kim H A, Jeon Y, Park S-S, Kim S, Lim D G, Kwak K-H
Transplant Proc. 2021 Jul 06.
PMID: 34238590.


Dexmedetomidine is known to protect against ischemia-reperfusion (IR) in various organs; however, the mechanisms of dexmedetomidine in the liver remain unclear. We investigated whether dexmedetomidine preconditioning leads to hepatic protection and whether nitric oxide was associated with this protective mechanism by employing N-nitro-l-arginine methyl ester (l-NAME), a nitrous oxide synthase inhibitor.