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Papers of the Week

Papers: 10 Jul 2021 - 16 Jul 2021

Human Studies


2021 Jul 09

J Eur Acad Dermatol Venereol

The right default mode network is associated with the severity of chronic itch.


Mochizuki H, Kursewicz CD, Nomi JS, Yosipovitch G
J Eur Acad Dermatol Venereol. 2021 Jul 09.
PMID: 34242425.


Itch severity in chronic itch patients is influenced by mental state. However, the brain network mediating this nuisance relationship remains unknown. The medial parietal cortex (MPC) is a key hub of the default mode network (DMN) that regulates the mental state and also a brain region selective for itch (i.e., itch, but not pain, activates the MPC). Moreover, antidepressants are used in the treatment of chronic itch and are well known to alter activity in DMN.