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Papers of the Week

2021 Jul 09

Clin Chem Lab Med

Quantitative profiling of inflammatory and pro-resolving lipid mediators in human adolescents and mouse plasma using UHPLC-MS/MS.


Hartling I, Cremonesi A, Osuna E, Lou P-H, Lucchinetti E, Zaugg M, Hersberger M
Clin Chem Lab Med. 2021 Jul 09.
PMID: 34243224.


Lipid mediators are bioactive lipids which help regulate inflammation. We aimed to develop an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method to quantify 58 pro-inflammatory and pro-resolving lipid mediators in plasma, determine preliminary reference ranges for adolescents, and investigate how total parenteral nutrition (TPN) containing omega-3 polyunsaturated fatty acid (n-3 PUFA) or n-6 PUFA based lipid emulsions influence lipid mediator concentrations in plasma.