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Papers of the Week

Papers: 3 Jul 2021 - 9 Jul 2021

Human Studies

2021 Jul-Aug

Pain Rep



C-tactile touch perception in patients with chronic pain disorders.


Gossrau G, Klimova A, Lapp H S, Frost M, Peschel E, Weidner K, Koch T, Sabatowski R, Croy I
Pain Rep. 2021 Jul-Aug; 6(2):e941.
PMID: 34235344.


Slow brushing over the skin activates C-tactile nerve fibers that transmit pleasant tactile experiences in healthy subjects, leading to an inverted U-shaped velocity dependence of ratings: C-tactile optimal stroking stimulations are rated as more pleasant than slower or faster stimulations. Chronic pain diseases such as postherpetic neuralgia (PHN) and complex regional pain syndrome show altered C-fiber innervation density, sensory loss, and pain sensitization.