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Papers of the Week

Papers: 3 Jul 2021 - 9 Jul 2021

Animal Studies, Pharmacology/Drug Development

2021 Jul 03

Life Sci

Raf1 interacts with OIP5 to participate in oxaliplatin-induced neuropathic pain.


Yu W, Zheng Z, Wei W, Li L, Zhang Y, Sun Y, Cao J, Zang W, Shao J
Life Sci. 2021 Jul 03:119804.
PMID: 34229010.


Oxaliplatin is an effective anti-cancer platinum-based chemotherapy drug which can cause severe chronic neuropathy, but the molecular mechanism underlying this adverse effect is still unclear. Opa interacting protein 5 (OIP5) is a member of the cancer/testis antigen (CTA) family and is involved in a variety of cancers. Studies have shown that Raf1, which is a serine/threonine-protein kinase, can directly combine with OIP5 to promote its expression. Whether Raf1 and OIP5 can participate in oxaliplatin-induced neuropathic pain has not been reported.