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Papers of the Week


2021 Jun 17


Plants (Basel)


10


6

The Anti-Inflammatory and the Antinociceptive Effects of Mixed Ledeb. and Bunge Extract.

Authors

Feng J-H, Kim H-Y, Sim S-M, Zuo G-L, Jung J-S, Hwang S-H, Kwak Y-G, Kim M-J, Jo J-H, Kim S-C, Lim S-S, Suh H-W
Plants (Basel). 2021 Jun 17; 10(6).
PMID: 34204404.

Abstract

Arthritis is a common condition that causes pain and inflammation in a joint. Previously, we reported that the mixture extract (ME) from Ledeb. (AP) and Bunge (SM) could ameliorate gout arthritis. In the present study, we aimed to investigate the potential anti-inflammatory and antinociceptive effects of ME and characterize the mechanism. We compared the anti-inflammatory and antinociceptive effects of a positive control, powder (PC). The results showed that one-off and one-week treatment of ME reduced the pain threshold in a dose-dependent manner (from 10 to 100 mg/kg) in the mono-iodoacetate (MIA)-induced osteoarthritis (OA) model. ME also reduced the plasma TNF-α, IL-6, and CRP levels. In LPS-stimulated RAW 264.7 cells, ME inhibited the release of NO, PGE, LTB, and IL-6, increased the phosphorylation of PPAR-γ protein, and downregulated TNF-α and MAPKs proteins expression in a concentration-dependent (from 1 to 100 µg/mL) manner. Furthermore, ME ameliorated the progression of ear edema in mice. In most of the experiments, ME-induced effects were almost equal to, or were higher than, PC-induced effects. Conclusions: The data presented here suggest that ME shows anti-inflammatory and antinociceptive activities, indicating ME may be a potential therapeutic for arthritis treatment.