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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats.

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2021 Jul


Pain Physician


http://www.ncbi.nlm.nih.gov/pubmed/34213877?dopt=Abstract


24


4

Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats.

Authors

Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats.
Rodrigues RF, Kawano T, Placido RV, Costa LH, Podesta MHMC, Santos RS, Galdino G, Barros CM, Boralli VB
Pain Physician. 2021 Jul; 24(4):E511-E520.
PMID: 34213877.

Abstract

Amitriptyline, duloxetine, and pregabalin are among the most pharmacotherapeutic, effective treatments for neuropathic pain control. However, the evaluation of synergism by combining these treatments is still poorly investigated.