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Papers of the Week

Papers: 26 Jun 2021 - 2 Jul 2021

Animal Studies


2021 Jun 30

J Headache Pain



CGRP induces migraine-like symptoms in mice during both the active and inactive phases.


Wattiez A-S, Gaul OJ, Kuburas A, Zorilla E, Waite JS, Mason BN, Castonguay WC, Wang M, Robertson BR, Russo AF
J Headache Pain. 2021 Jun 30; 22(1):62.
PMID: 34193048.


Circadian patterns of migraine attacks have been reported by patients but remain understudied. In animal models, circadian phases are generally not taken into consideration. In particular, rodents are nocturnal animals, yet they are most often tested during their inactive phase during the day. This study aims to test the validity of CGRP-induced behavioral changes in mice by comparing responses during the active and inactive phases.