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Papers of the Week

2021 Jun 24

J Neuroinflammation



Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice.


Shao S, Xu C-B, Chen C-J, Shi G-N, Guo Q-L, Zhou Y, Wei Y-Z, Wu L, Shi J-G, Zhang T-T
J Neuroinflammation. 2021 Jun 24; 18(1):142.
PMID: 34162415.


Chronic neuropathic pain is a frequent sequel to peripheral nerve injury and maladaptive nervous system function. Divanillyl sulfone (DS), a novel structural derivative of 4,4'-dihydroxydibenzyl sulfoxide from a traditional Chinese medicine Gastrodia elata with anti-nociceptive effects, significantly alleviated neuropathic pain following intrathecal injection. Here, we aimed to investigate the underlying mechanisms of DS against neuropathic pain.