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Papers of the Week

2021 Jun 21

Pulm Pharmacol Ther

A phase 1, randomized study to evaluate safety, tolerability, and pharmacokinetics of GDC-3280, a potential novel anti-fibrotic small molecule, in healthy subjects.


Cheung D, Fong A, Ding H T, Cabanski CR, Wang J, Chen Y, Bush J, Harris JM, Pan L
Pulm Pharmacol Ther. 2021 Jun 21:102051.
PMID: 34166834.


Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease. Although anti-fibrotic treatments, such as pirfenidone, are available that reduce the rate of disease progression, these medications have limitations in tolerability, and IPF patients still have poor prognoses. GDC-3280, an orally available small molecule that was designed to improve upon pirfenidone's activity, has anti-fibrotic activity in animal models. This first-in-human, phase 1 trial evaluated GDC-3280 to determine its safety, tolerability, and pharmacokinetics (PK).