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Papers of the Week

2021 Jun 24

Eur Surg Res

Long-Term Analgesia following a Single Application of Fentanyl Transdermal Solution in Pigs.


Goutchtat R, Chetboun M, Wiart J-F, Gaulier J-M, Pattou F, Allorge D, Hubert T
Eur Surg Res. 2021 Jun 24:1-6.
PMID: 34167112.


In animal research, obtaining efficient and constant pain control is regulatory but challenging. The gold standard pain management consists of opioid analgesic administration, such as buprenorphine or fentanyl extended-release patches. However, as in all drugs with a short half-life time, repeated buprenorphine administrations are needed, leading to multiple injections that affect the research protocol. On the other hand, fentanyl patch efficacy is discussed in some species. These elements highlight the need of an optimal formulation of analgesic drugs for laboratory animals. In this study, we investigated how Recuvyra®, a fentanyl transdermal solution (FTS), validated in dog perioperative pain management, could provide sustained analgesia after a single topical administration in pigs in a surgical context.