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Papers of the Week

Papers: 19 Jun 2021 - 25 Jun 2021

Human Studies

2021 Jun 24

BMC Rheumatol



Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study.


Ifesemen OS, McWilliams DF, Ferguson E, Wakefield R, Akin-Akinyosoye K, Wilson D, Platts D, Ledbury S, Walsh DA
BMC Rheumatol. 2021 Jun 24; 5(1):23.
PMID: 34162435.


Pain and fatigue are persistent problems in people with rheumatoid arthritis. Central sensitisation (CS) may contribute to pain and fatigue, even when treatment has controlled inflammatory disease. This study aims to validate a self-report 8-item questionnaire, the Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA) questionnaire, developed to measure central pain mechanisms in RA, and to predict patient outcomes and response to treatment. A secondary objective is to explore mechanisms linking CS, pain and fatigue in people with RA.