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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / IL4-10 Fusion Protein Shows DMOAD Activity in a Rat Osteoarthritis Model.

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Papers: 19 Jun 2021 - 25 Jun 2021


Animal Studies, Pharmacology/Drug Development


2021 Jun 23


Cartilage


http://www.ncbi.nlm.nih.gov/pubmed/34159843?dopt=Abstract

IL4-10 Fusion Protein Shows DMOAD Activity in a Rat Osteoarthritis Model.

Authors

IL4-10 Fusion Protein Shows DMOAD Activity in a Rat Osteoarthritis Model.
van Helvoort EM, de Visser HM, Lafeber FPJG, Coeleveld K, Versteeg S, Weinans HH, Popov-Celeketic J, Eijkelkamp N, Mastbergen SC
Cartilage. 2021 Jun 23:19476035211026736.
PMID: 34159843.

Abstract

Ideally, disease-modifying osteoarthritis (OA) drugs (DMOAD) should combine chondroprotective, anti-inflammatory, and analgesic effects in a single molecule. A fusion protein of interleukin-4 (IL-4) and IL-10 (IL4-10 FP) possesses these combined effects. In this study, the DMOAD activity of rat IL4-10 FP (rIL4-10 FP) was tested in a rat model of surgically induced OA under metabolic dysregulation.
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