I am a
Home I AM A Search Login

Papers of the Week

Papers: 19 Jun 2021 - 25 Jun 2021

Human Studies

2021 Jun 22

J Gene Med

Genetic variation in catechol-O-methyltransferase is associated with individual differences in conditioned pain modulation in healthy subjects.


Korczeniewska OA, Kuo F, Huang C-Y, Nasri-Heir C, Khan J, Benoliel R, Hirschberg C, Eliav E, Diehl SR
J Gene Med. 2021 Jun 22:e3374.
PMID: 34156736.


Genetic variation in the catechol-O-methyltransferase (COMT) gene is associated with sensitivity to both acute experimental pain and chronic pain conditions. Four single nucleotide polymorphisms (SNPs) have traditionally been used to infer three common haplotypes designated as low, average and high pain sensitivity (LPS, APS and HPS) and are reported to affect both COMT enzymatic activity and pain sensitivity. One mechanism that may partly explain individual differences in sensitivity to pain is Conditioned Pain Modulation (CPM). We hypothesized that variation in CPM may have a genetic basis.