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Papers of the Week

Papers: 12 Jun 2021 - 18 Jun 2021

Human Studies


2021 Jun 14

J Headache Pain



A genetic interaction of NRXN2 with GABRE, SYT1 and CASK in migraine patients: a case-control study.


Alves-Ferreira M, Quintas M, Sequeiros J, Sousa A, Pereira-Monteiro J, Alonso I, Neto J L, Lemos C
J Headache Pain. 2021 Jun 14; 22(1):57.
PMID: 34126933.


Migraine is a multifactorial disorder that is more frequent (two to four times) in women than in men. In recent years, our research group has focused on the role of neurotransmitter release and its regulation. Neurexin (NRXN2) is one of the components of the synaptic vesicle machinery, responsible for connecting intracellular fusion proteins and synaptic vesicles. Our aim was to continue exploring the role and interaction of proteins involved in the control and promotion of neurotransmission in migraine susceptibility.