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Papers of the Week

2021 Jun 10

CNS Neurosci Ther

Spinal microglial β-endorphin signaling mediates IL-10 and exenatide-induced inhibition of synaptic plasticity in neuropathic pain.


Ma L, Peng S, Wei J, Zhao M, Ahmad K A, Chen J, Wang Y-X
CNS Neurosci Ther. 2021 Jun 10.
PMID: 34111331.


This study aimed to investigate the regulation of pain hypersensitivity induced by the spinal synaptic transmission mechanisms underlying interleukin (IL)-10 and glucagon-like peptide 1 receptor (GLP-1R) agonist exenatide-induced pain anti-hypersensitivity in neuropathic rats through spinal nerve ligations.