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Papers: 5 Jun 2021 - 11 Jun 2021

Human Studies

2021 Jun 09

Pain Manag

Preliminary effects of low-intensity focused ultrasound treatment program for cancer-related neuropathic pain.


Patel AA, Zhukosvky M, Sidharthan S, Jotwani R, Rakesh N, Gulati A
Pain Manag. 2021 Jun 09.
PMID: 34102872.


To evaluate the effectiveness of low-intensity focused ultrasound (LIFU) therapy in the management of cancer-related neuropathic pain (CNP). A retrospective review with 22 patients with CNP treated with LIFU therapy (frequency 3 Hz, 3 W/cm, pulse mode duty cycle 50%) was conducted. Out of the 22 patients, 15 had CNP secondary to chemotherapy-induced peripheral neuropathy. Compared with baseline, there was a significant reduction in numeric pain rating scale (p < 0.001). Additionally, 76.5% of patients (n = 13) were considered to be responders to LIFU therapy. LIFU therapy may be a viable treatment modality in the management of CNP, specifically chemotherapy-induced peripheral neuropathy, with a minimal side effect profile. Larger, prospective studies with a structured protocol are necessary.