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Papers of the Week

Papers: 5 Jun 2021 - 11 Jun 2021

Animal Studies, Pharmacology/Drug Development

2021 Jul-Aug

Pain Rep



Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice.


Meloto CB, Ingelmo P, Perez E V, Pitt R, González Cárdenas V H, Mohamed N, Sotocinal SG, Bourassa V, Lima L V, Ribeiro-da-Silva A, Mogil JS, Diatchenko L
Pain Rep. 2021 Jul-Aug; 6(2):e902.
PMID: 34104835.


Mast cell (MC) activation could establish a positive feedback loop that perpetuates inflammation and maintains pain. Stabilizing MCs with ketotifen fumarate (KF) may disrupt this loop and relieve pain.