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Papers of the Week

2021 Jun 05

Biomed Eng Online



Three-dimensional analysis of the characteristics of joint motion and gait pattern in a rodent model following spinal nerve ligation.


Seto T, Suzuki H, Okazaki T, Imajo Y, Nishida N, Funaba M, Kanchiku T, Taguchi T, Sakai T
Biomed Eng Online. 2021 Jun 05; 20(1):55.
PMID: 34090446.


The spinal nerve ligation (SNL) rat is well known as the most common rodent model of neuropathic pain without motor deficit. Researchers have performed analyses using only the von Frey and thermal withdrawal tests to evaluate pain intensity in the rat experimental model. However, these test are completely different from the neurological examinations performed clinically. We think that several behavioral reactions must be observed following SNL because the patients with neuropathic pain usually have impaired coordination of the motions of the right-left limbs and right-left joint motion differences. In this study, we attempted to clarify the pain behavioral reactions in SNL rat model as in patients. We used the Kinema-Tracer system for 3D kinematics gait analysis to identify new characteristic parameters of each joint movement and gait pattern.