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Papers of the Week

2021 Jul

J Orthop Translat


Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model.


Wang R, Li J, Xu X, Xu J, Jiang H, Lv Z, Wu R, Sun Z, Guo W, Sun Y, Ikegawa S, Jiang Q, Shi D
J Orthop Translat. 2021 Jul; 29:89-99.
PMID: 34094861.


Synovial inflammation plays a major role in the pathogenesis of osteoarthritis (OA). This study investigated the effect of andrographolide (Andro) on synovial inflammation mediated by tumor necrosis factor-alpha receptor 2 (TNFR2) trafficking and its utility in attenuating OA progression.