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Papers of the Week

Papers: 5 Jun 2021 - 11 Jun 2021

Human Studies, Pharmacology/Drug Development


PLoS One



S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial.


Brinck E C, Virtanen T, Mäkelä S, Soini V, Hynninen V-V, Mulo J, Savolainen U, Rantakokko J, Maisniemi K, Liukas A, Olkkola KT, Kontinen V, Tarkkila P, Peltoniemi M, Saari TI
PLoS One. 2021; 16(6):e0252626.
PMID: 34097713.


Spinal fusion surgery causes severe pain. Strong opioids, commonly used as postoperative analgesics, may have unwanted side effects. S-ketamine may be an effective analgesic adjuvant in opioid patient-controlled analgesia (PCA). However, the optimal adjunct S-ketamine dose to reduce postoperative opioid consumption is still unknown.